What is it used for (Indication) ?
Mometasone furoate (also referred to as mometasone) is a glucocorticoid steroid used topically to reduce inflammation of the skin disorder(such as eczema and psoriasis), allergic rhinitis (such as hay fever), lichen planus, bug bites, burns, asthma for patients unresponsive to less potent corticosteroids, and penile phimosis.
How it works (Mechanism)?
Mometasone is in a class of medications called Corticosteroid. It reduces inflammation by causing several effects as follows :
- Reverses the activation of inflammatory genes
- Activates the secretion of anti-inflammatory proteins
- Stabilises cell membranes
- Decreases the influx of inflammatory cells
What is Allergic Rhinitis, Asthma , Eczema, Psoriasis, Lichen Planus, and Penile Phimosis (disease) ?
Allergic rhinitis: Allergic rhinitis, more commonly referred to as hay fever, is an inflammation of the nasal passages caused by allergic reaction to airborne substances. There are two types of allergic rhinitis: seasonal and perennial. Seasonal AR occurs in the spring, summer, and early fall, when airborne plant pollens are at their highest levels. In fact, the term hay fever is really a misnomer, since allergy to grass pollen is only one cause of symptoms for most people. Perennial AR occurs all year and is usually caused by home or workplace airborne pollutants. A person can be affected by one or both types. Symptoms of seasonal AR are worst after being outdoors, while symptoms of perennial AR are worst after spending time indoors.
Asthma: Asthma is a chronic (long-lasting) inflammatory disease of the airways. In those susceptible to asthma, this inflammation causes the airways to narrow periodically. This, in turn, produces wheezing and breathlessness, sometimes to the point where the patient gasps for air. Obstruction to air flow either stops spontaneously or responds to a wide range of treatments, but continuing inflammation makes the airways hyper-responsive to stimuli such as cold air, exercise, dust mites, pollutants in the air, and even stress and anxiety. In an asthma attack, the muscle tissue in the walls of bronchi go into spasm, and the cells lining the airways swell and secrete mucus into the air spaces. Both these actions cause the bronchi to become narrowed (bronchoconstriction). As a result, an asthmatic person has to make a much greater effort to breathe in air and to expel it. Asthma usually begins in childhood or adolescence, but it also may first appear during adult years. While the symptoms may be similar, certain important aspects of asthma are different in children and adults.
Eczema: Eczema is a form of dermatitis, or inflammation of the epidermis (the outer layer of the skin). It is a range of persistent skin conditions that include dryness and recurring skin rashes, characterized by one or more of these symptoms: redness, skin edema (swelling), itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. Areas of temporary skin discoloration may appear and are sometimes due to healed lesions. Scratching open a healing lesion may result in scarring and may enlarge the rash. Types of eczemas include atopic eczema, contact dermatitis, xerotic eczema, and seborrhoeic dermatitis.
Psoriasis: Psoriasis is a chronic, autoimmune disease that appears on the skin. Psoriasis is classified into nonpustular and pustular. The various types of psoriasis include plaque, guttate, pustular, inverse, and erythrodermic. It is not contagious. It occurs when the immune system sends out faulty signals that speed up the growth cycle of skin cells. It commonly causes red, scaly patches to appear on the skin, although some patients have no dermatological symptoms. The scaly patches caused by psoriasis, called psoriatic plaques, are areas of inflammation and excessive skin production. Skin rapidly accumulates at these sites which gives it a silvery-white appearance. Plaques frequently occur on the skin of the elbows and knees, but can affect any area including the scalp, palms of hands and soles of feet, and genitals. In contrast to eczema, psoriasis is more likely to be found on the outer side of the joint. Psoriasis can also cause inflammation of the joints, which is known as psoriatic arthritis.
Lichen Planus: Lichen sclerosus (LS) is also known as Lichen Sclerosus et Atrophicus (LSA), Balanitis xerotica obliterans (BXO), Csillag's disease, White Spot Disease and kraurosis vulvae. Typically it's called LSA or BXO when it affects men, LS when it affects women or in referring to the disease in general. LS is an uncommon disease of unknown cause that results in white patches on the skin, which may cause scarring on and around genital skin. Several risk factors have been proposed, including autoimmune diseases, infections and genetic predisposition. Women are more commonly affected than men, particularly around and after menopause, but younger women or girls may also develop the disease. The condition most commonly occurs on the vulva and around the anus with ivory-white elevations that may be flat and glistening. There may be marked itching or the condition may be without any symptoms. There may also be thinning and shrinkage of the genital area that may make coitus, urination and defecation painful. In males, the disease may take the form of whitish thickening of the foreskin, which cannot be retracted easily (phimosis). In contrary to women, there is no perianal involvement. In men, this genital involvement has traditionally been known as balanitis xerotica obliterans (BXO). On the non-genital skin, the disease may manifest as porcelain-white spots with small visible plugs inside the orifices of hair follicles or sweat glands on the surface. Thinning of the skin may also occur.
Penile Phimosis: It refers to tightening of the foreskin of the penis that may close the opening of the penis. Phimosis (or foreskin contraction) is caused by the inability of the foreskin to retract from around the opening of the penis. It may produce urinary obstruction with ballooning of the foreskin. In adults, phimosis can lead to chronic inflammation and cancer. The foreskin of a newborn boy is always closely contracted around the penis head (glans). Only a small passage allows the urine to pass through. In the first months the foreskin is stuck to the glans and cannot be pulled back and one should not attempt to do so. During the first couple of years, the foreskin will become gradually looser and in many boys it can in time be pulled back without trouble. Half of all three-year-olds can pull back their foreskin. It is not advisable to try pulling the foreskin back using force, since this may cause small cuts in the foreskin with scars which could finally cause a regular foreskin contraction. If the foreskin cannot be pulled back into place treatment should be sought. Failure to seek treatment can result in permanent damage to the penis. If phimosis in older children or adults is not causing acute and severe problems, nonsurgical measures may be effective and application of topical steroid cream is less expensive than surgical treatments and is highly effective.
How to take this medicine (Administration & Dosage) ?
- Mometasone comes as a cream to apply on the skin.
- It is used once a day.
- Clean and dry the infected area, apply a thin film to the affected area and gently rub in until it disappears.
- Wash your hands before and after each application.
- Avoid getting it into your eyes, nose, or mouth.
- Do not swallow it.
- Do not use more or less of it or use more often than prescribed; it can be absorbed into your body if used in large amounts causing harmful effects.
- Do not use it for longer than 2 weeks.
- Discontinue its use when control has been achieved.
- Do not cover or apply dressings, bandages, cosmetics, lotions, or other skin medicines to the infected area, unless otherwise directed by your doctor.
- Inform your doctor if your condition persists or worsens after 2 weeks.
- Monitor periodically for evidence of HPA axis suppression.
- Monitor periodically your child's growth rate and height..
- Report immediately signs of adverse reactions to your doctor if any.
- Not recommended its use in children under 2 years of age.
- Do not apply it on sore, ulcer or cut.
Side effects of medicine
This medication is generally well tolerated. Common side effects include burning, itching, stinging, irritation, or redness when you apply it for the first time. However, if problems like persistent headache, vision problem, increase of thirst or urination, weight loss, weakness or dizziness occurs immediately notify your doctor.
Interaction with other medicines
If you are using any other medications while taking this medicine such as oral corticosteroids, prednisone or cyclosporine for suppressing immune system or other.
Contraindications (Who should avoid this)
- If you are hypersensitive to Mometasone or any of its component.
- If you are pregnant or planning to be pregnant.
- If you are breast feeding.
- If you are a patient with poor blood circulation, immune system problem, any serious infections, injuries or surgeries.
1. Keep away from light and moisture.
2. Store at room temperature between 15° - 30° C (59° - 86° F).
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