It is used to treat fungal infections such as blastomycosis, histoplasmosis and onychomycosis (fungal infection of the nail). It is also prescribed for systemic infections such as aspergillosis, candidiasis (fungal infection of skin, mucosal membranes and vagina) and cryptococcosis.

It is a triazole antifungal that inhibits the fungal synthesis of ergosterol (component of fungal cell membrane) which prevents growth of fungus.

Blastomycosis: - Also known as "North American blastomycosis," "Blastomycetic dermatitis," and "Gilchrist's disease" is a fungal infection caused by the organism Blastomyces dermatitidis.

Histoplasmosis: - Also known as "Cave disease," "Darling's disease," "Ohio valley disease," and "Reticuloendotheliosis") is a disease caused by the fungus Histoplasma capsulatum. Symptoms of this infection vary greatly, but the disease primarily affects the lungs.

Onychomycosis: - Also known as "Dermatophytic onychomycosis,","Ringworm of the nail," and "Tinea unguium" means fungal infection of the nail. Aspergillosis: - It is the wide variety of diseases caused by fungi of the genus Aspergillus.

Candidiasis: - It is a fungal infection (mycosis) of any of the Candida species, of which Candida albicans is the most common infection. Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systemic and potentially life-threatening diseases.

Cryptococcosis: - Also known as cryptococcal disease, is a potentially fatal fungal disease. It is caused by members of the Cryptococcus neoformans species complex acquired by inhalation of the infectious propagule from the environment.

1. It should be taken in dose of 200 mg once or twice daily as directed by your physician.
2. Maximum dose is 400 mg once daily.
3. It should be taken with food.
4. It should be taken 2 hours before taking antacids or other acid reducing medications like ranitidine.
5. If dose is missed, take it as soon as possible. Skip the dose if it is almost the time for next dose.

It may show some common side effects which include nausea, vomiting, diarrhea, rash, edema, fatigue and dizziness.

It may interact with :

1. Blood thinners like warfarin
2. Antiepileptic like phenytoin
3. Anti-diabetic drug like glyburide, glipizide
4. HIV, AIDS drugs like indinavir
5. Hypolipidemic like simvastatin
6. Anxiolytic like midazolam
7. Calcium channel blocker like verapamil
8. Anticonvulsant like carbamazepine
9. Macrolide antibiotic like erythromycin

1. If you are hypersensitive to it or any of its ingredients.
2. If you are suffering from any hepatic disease.
3. If you are pregnant, plan to become pregnant, or are breast-feeding.
4. Avoid taking
   • HMG-CoA reductase inhibitors like lovastatin, simvastatin
   • Aldosterone blocker like eplerenone
   • 5-HT receptor agonists like eletriptan
   • Quinazoline like alfuzosin

1. Keep away from light and moisture.
2. Store at room temperature between 15° - 30° C (59° - 86° F).

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